Neurological syndromes associated with medication use

Neurological syndromes associated with medication use.

Neurological syndromes associated with drug use. Frequency and characterisation.

INTRODUCTION The need for safe health care, in which the care and treatment of the patient does not cause any injuries in addition to those already arising from their baseline disease, has led to the present study. Our objective has been to determine the frequency and describe the neurological syndromes attributable to drugs, their preventability and the levels of medical care involved. METHO...

Antibodies to TRIM46 are associated with paraneoplastic neurological syndromes

Paraneoplastic neurological syndromes (PNS) are often characterized by the presence of antineuronal antibodies in patient serum or cerebrospinal fluid. The detection of antineuronal antibodies has proven to be a useful tool in PNS diagnosis and the search for an underlying tumor. Here, we describe three patients with autoantibodies to several epitopes of the axon initial segment protein tripart...

Immunopathogenesis of paraneoplastic neurological syndromes associated with anti-Hu antibodies

Paraneoplastic neurological disorders (PNDs) are syndromes that develop in cancer patients when an efficient antitumor immune response, directed against antigens expressed by both malignant cells and healthy neurons, damages the nervous system. Herein, we analyze existing data on the mechanisms of loss of self tolerance and nervous tissue damage that underpin one of the most frequent PNDs, the ...

Reversible ischaemic neurological deficit associated with short-term methylphenidate medication.

Methylphenidate is a central nervous system stimulant pharmacologically related to amphetamines frequently used in attention deficit hyperactivity disorder (ADHD) and narcolepsy. Haemorrhagic stroke is a rare but well-known potential side-effect of amphetamine abuse, however, cerebral ischaemia has been reported casuistically (Rothrock et al., 1988). Here, we present incidence of a reversible i...